Establishing the Superiority of Topical Diltiazem over Glyceryl Trinitrate in the Treatment of Chronic Anal Fissure: a Prospective Analytical Study
نویسندگان
چکیده
Introduction: Anal fissure is a common ailment of young age group, affecting males and females alike. Traditionally surgery has been the 1st line of treatment but recently the topical agents such as Glyceryl Trinitrate and Diltiazem are replacing the surgical treatment as preferred modality. Objective: The present study was conducted to compare the topical GTN and DTZ in terms of effectiveness, side effects and patient satisfaction. Material and methods: The study was conducted on 50 patients who were divided into 2 groupsGroup I and Group II. Group I patients were treated with topical 2% DTZ while Group II patients were put on topical 0.2% GTN. Cases were kept in follow up for 6 weeks and data thus gathered was analyzed. Results: No significant difference was noted in both groups in term of relief in pain, bleeding and fissure healing. However group II patients reported a higher incidence of headache associated with Topical GTN usage, when compared with the Group II patients (p <0.05). Conclusion: Topical Diltiazem is preferred to topical Glyceryl trinitrate as it is better tolerated with a fewer side effects Hence 2% DTZ should be considered as 1st line of therapy for the treatment of chronic anal fissure.
منابع مشابه
Topical Diltiazem versus topical Glyceryl trinitrate (GTN) in the treatment of chronic anal fissure: Prospective study
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Topical diltiazem hydrochloride and glyceryl trinitrate in the treatment of chronic anal fissure.
OBJECTIVE To compare the symptomatic relief, healing and side-effects of topical diltiazem (DTZ) and glyceryl trinitrate in the treatment of chronic anal fissure. STUDY DESIGN Randomized controlled trial. PLACE AND DURATION OF STUDY The Surgical Outpatient Department of Civil Hospital, Karachi, from March 2006 to February 2007. METHODOLOGY Patients with chronic anal fissure were included ...
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BACKGROUND Anal fissure is a linear tear in the distal anal canal resulting from persistent hypertonia and spasm of the internal sphincter which results in mucosal ischemia. We have conducted a study in order to compare the outcome of 0.2% glyceryl trinitrate cream versus 2% diltiazem cream in the treatment of chronic anal fissure. METHODS This randomized controlled trial (RCT) was carried ou...
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Introduction: Chronic anal fissure is associated with anal hypertonia and considerable pain. Internal sphincter pressure decreases with surgical procedures or medical agents. Numerous clinical studies have evaluated the effectiveness of multiple drugs. Objective: This study compared the efficacy of diltiazem 2% compared to glycerol trinitrate 0.2% for chemical sphincterotomy. Materials & Me...
متن کاملDiltiazem vs. glyceryl tri-nitrate for symptomatic relief in anal fissure: a randomised clnical study.
OBJECTIVE To further resolve the clinical equipoise on the choice of chemical sphincterotomy agent for early symptomatic relief of anal fissure by comparing the effectiveness of 2% Diltiazem gel with 0.2% Glyceryl TriNitrate. METHODS The randomized clinical trial was conducted at Aga Khan University Hospital, Karachi, from February 1, to July 30, 2008, and comprised 60 adult patients with ana...
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